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#1 2008-03-28 06:51:22

orgopete
Administrator

green chem

If you calculate this out, I think it is a catalytic amount of hydroxide to do the first step of the aldol condensation. Then an excess is used for the dehydration step and heating.

By using vanillin, you have a phenol present. Increase the amount of NaOH to allow the phenol to become completely converted to the phenoxide and add the same amount of additional base to enolize the indanone. Because the vanillin the electron density of the vanillin will have increased, it will react more slowly than the dimethoxybenzaldehyde.

From that point, carry out the procedure as described.

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